The Research Ethics Committee of Shiraz University of Medical Sciences approved the protocol of this study (approval number: ). All the participants were volunteers who were informed about objectives and method of the study and signed a written consent form. Data collection was undertaken between August 2012 and March The participants were interviewed by a research assistant before completing the questionnaires. PO Box:, Tel:, Fax: ,ΔΆ Neurology Asia September 2015 as a dependent variable. Nahid Ashjazadeh, Shiraz Neuroscience Research Center, Chamran Hospital, Chamran Boulevard, Shiraz, Iran. Three predictor variables, including resilience, treatment adherence and severity of sickness, were used and QOL was considered Address correspondence to: Dr. METHODS We performed a descriptive, study, using multiple regressions. The hypothesis of this study is that there is a significant correlation between psychological resilience, adherence to treatment, and expanded disability status of patients with MS and their physical and mental components of health-related QOL. 3 This study aims to assess the impact of adherence to treatment, severity of illness, and psychological resilience on the health-related QOL inthe Iranian patients with MS. 9,10 Treatment adherence problems and disability status have a negative effect on QOL 1,11, while psychological resilience has a positive impact on QOL in patients with MS.
6-8 Psychological resilience is the patients ability to properly adapt and cope with her/his disease which has a positive role in QOL of patients. 5 However, similar to other chronic diseases, treatment adherence is a common problem and it has been shown that cases with good adherence suffer from fewer relapses and have better QOL compared with poor adherence cases.
1-4 Discovery and development of several types of disease modifying drugs changes the disabling course of MS by reducing relapses and slowing disease progression. Both somatic symptoms such as weakness, spasticity, pain and non-somatic ones such as affective and cognitive impairments have a negative influence on different domains of QOL. 1 Distribution and severity of demyelinating and degenerative lesions in the brain and spinal cord of these patients are associated with a variety of symptoms which can impact adversely on the health-related quality of life (QOL) in these patients. INTRODUCTION Multiple sclerosis (MS) is a common neurologicaldisorder which mostly affects the active adult population. Both psychological resilience and treatment adherence have positive influence on mental component of QOL in these patients. Conclusion: The findings showed that the severity of the disease is a strong predictor which has adverse effects on the physical component of health-related QOL in the patients with MS. In the second model, both the disability status and resilience explained 50.6% of the variation in QOL.
Results: Stepwise multiple regressions showed that in the first model, the disability status was the best predictor which accounted for 28.1% of the variance in QOL. Medication adherence and severity of disease were assessed by the Morisky Medication Adherence Scale (MMAS) and expanded disability status state (EDSS) scores respectively. The QOL and resilience were evaluated by the Medical Outcomes Study Short-Form (SF-36) and Connor-Davidson Resilience Scale (CD-RISC) respectively. MS was diagnosed by 2010 revised Mc-Donald criteria. Methods: One hundred MS outpatients, 80 women and 20 men, referred to a clinic of Shiraz University of Medical Sciences, were eligible to participate. 1 Neurology Asia 2015 20(3) : The role of psychological resilience, severity of disease and treatment adherence in the prediction of health-related quality of life in patients with multiple sclerosis 1 Habib Hadianfard MD, 2 Nahid Ashjazadeh MD, 1 Soodabe Feridoni BS, 1 Elham Farjam BS 1 Department of Clinical Psychology, Shiraz University, Shiraz 2 Shiraz Neuroscience Research Center, Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran Abstract Objective: This cross-sectional study aims to evaluate the impact of the disability status, psychological resilience, and treatment adherence on health-related quality of life (QOL) in patients with multiple sclerosis (MS).